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3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

20 Oct 2020

Abstract excerpt

Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca 2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating CatSper-dependent mechanisms in sperm selection. Here using biochemical and pharmacological studies, we demonstrate that CatSper1 is an O-linked glycosylated protein,...

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PMID: 33078708
DOI: 10.7554/elife.62043

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