The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction

Abstract excerpt

Ca(2+) influx triggers sperm capacitation; however, the underlying regulatory mechanisms remain incompletely understood. Here, we show that CNNM4, a Mg(2+) transporter, is required for Ca(2+) influx during capacitation. We find that Cnnm4-deficient male mice are almost infertile because of sperm dysfunction. Motion analyses show that hyperactivation, a qualitative change in the mode of sperm motility during...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Magnesium in Health and Disease
• Share to Reproductive Biology and Fertility
• Share to Sperm and Testicular Function