Article

Functional characteristics and computational model of abundant hyperactive loci in the human genome

2023-02-05

Abstract excerpt

Enhancers and promoters are classically considered to be bound by a small set of TFs in a sequence-specific manner. This assumption has come under increasing skepticism as the datasets of ChIP-seq assays of TFs have expanded. In particular, high-occupancy target (HOT) loci attract hundreds of TFs with often no detectable correlation between ChIP-seq peaks and DNA-binding motif presence. Here, we used a set of 1,00...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ef3f805-bff1-53a2-8748-e90fe60f2e66
DOI: 10.1101/2023.02.05.527203

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional characteristics and computational model of abundant hyperactive loci in the human genomeDOI 10.1101/2023.02.05.527203Read

Genome-wide identification and characterisation of HOT regions in the human genomeSemantic proximity Read

Functional annotation of HOT regions in the human genome: implications for human disease and cancer.Semantic proximity Read

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associationsSemantic proximity Read

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations.Semantic proximity Read

Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolutionSemantic proximity Read

Super-enhancers are transcriptionally more active and cell-type-specific than stretch enhancersSemantic proximity Read

PEhub resolves the hierarchical regulatory architecture of multi-way enhancer hubs in the human brainSemantic proximity Read

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.Semantic proximity Read

Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease lociSemantic proximity Read

spatzie: An R package for identifying significant transcription factor motif co-enrichment from enhancer-promoter interactionsSemantic proximity Read

Occupancy patterns of 208 DNA-associated proteins in a single human cell typeSemantic proximity Read

Integrative analysis of transcription factor occupancy at enhancers and disease risk loci in noncoding genomic regionsSemantic proximity Read