Article

Polygenic backgrounds influence phenotypic consequences of variants in cells, individuals, and populations

2025-01-07

Abstract excerpt

Both rare and common genetic variants contribute to human disease, and emerging evidence suggests that they combine additively to influence disease liability. However, the non-linear relationship between disease liability and disease prevalence means that risk variants may have more severe phenotypic consequences in high-risk polygenic backgrounds and minimal impact in low-risk backgrounds, resulting in uneven sel...

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Identifiers and source

Literature Corpus work: 7fce87fd-7a61-5190-bad9-51ef789f1950
DOI: 10.1101/2025.01.07.631805

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