Lidocaine alleviates pulmonary fibrosis by attenuating fibroblast activation and restoring lung microbiome-metabolome homeostasis

Abstract excerpt

<title>Abstract</title> <p>Pulmonary fibrosis is a devastating disease with limited treatment options. Lidocaine, a local anesthetic, has demonstrated anti-inflammatory and anti-tumor properties, but its therapeutic potential and mechanisms in pulmonary fibrosis remain largely unexplored. In this study, lidocaine administration significantly attenuated bleomycin (BLM)-induced lung injury and fibrosis. Lidocaine s...

Topics

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• ATP Synthase and ATPases Research
• Chemotherapy-induced cardiotoxicity and mitigation
• Chronic Obstructive Pulmonary Disease (COPD) Research
• Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Lung Cancer Treatments and Mutations
• Peptidase Inhibition and Analysis

Identifiers and source

Literature Corpus work

2d65760d-2069-5630-bb86-60ac34f3f2ab

DOI

10.21203/rs.3.rs-8111009/v1