Article

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with a poor prognosis. While pirfenidone and nintedanib offer some benefits, they cannot cure IPF. Nintedanib inhibits various proliferative pathways and has antifibrotic effects, but its molecular mechanisms and impact on the lung transcriptome in vivo remain unclear. This study aims to eva...

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Literature Corpus work: 366a55e7-4856-57b4-8cb0-05034b182a49
DOI: 10.1101/2024.10.30.620876

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