Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis

23 May 2025

Abstract excerpt

Doxorubicin (DOX) is a key chemotherapeutic agent but is also a leading cause of DOX-induced cardiotoxicity (DIC), limiting its clinical use. Akkermansia muciniphila (A. muciniphila), known for its benefits as a probiotic in treating metabolic syndrome, has uncertain effects in the context of DIC. Here, 16S rRNA sequencing of fecal samples from anthracycline-treated patients and DIC mice revealed marked depletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Synthase and ATPases Research
Share to Chemotherapy-induced cardiotoxicity and mitigation
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40410194
DOI: 10.1038/s41522-025-00712-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesisPMID 40410194Read ↗

NLRP3 inflammasome regulates doxorubicin-induced cardiotoxicity by modulating the abundance of gut microbiotaSemantic proximity Read ↗

Involvement of Abnormal Gut Microbiota Composition and Function in Doxorubicin-Induced CardiotoxicitySemantic proximity Read ↗

Akkermansia muciniphila alleviates metabolic disorders through gut microbiota-mediated tryptophan regulationSemantic proximity Read ↗

Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced CardiotoxicitySemantic proximity Read ↗

Multi-walled carbon nanotubes exacerbate doxorubicin-induced cardiotoxicity by altering gut microbiota and pulmonary and colonic macrophage phenotype in mice.Semantic proximity Read ↗

Antibiotic-associated changes in Akkermansia muciniphila alter its effects on host metabolic health.Semantic proximity Read ↗

Dapagliflozin-affected endothelial dysfunction and altered gut microbiota in mice with heart failureSemantic proximity Read ↗

Antibiotics-Induced Obesity: A Mitochondrial Perspective.Semantic proximity Read ↗

Aromatic Microbial Metabolite Hippuric Acid Potentiates Pro-Inflammatory Responses in Macrophages through TLR-MyD88 Signaling and Lipid RemodelingSemantic proximity Read ↗

Exploring the cardiotoxic potential of fumonisin B1 through inflammatory pathways and epigenetic modifications: A mini reviewSemantic proximity Read ↗

Mitochondria and Doxorubicin-Induced Cardiomyopathy: A Complex InterplaySemantic proximity Read ↗

Annexin-A1 deficiency attenuates stress-induced tumor growth via fatty acid metabolism in mice: an Integrated multiple omics analysis on the stress- microbiome-metabolite-epigenetic-oncology (SMMEO) axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.