Article

Cell-Specific Modulation of the Aryl Hydrocarbon Receptor by Kynurenine in Pulmonary Fibrosis Requires Microenvironmental Crosstalk

2026-07-22

Abstract excerpt

<h4>Background</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic lung disease with limited therapeutic options. Tryptophan metabolism is significantly dysregulated during lung fibrogenesis, with the metabolite kynurenine (kyn) accumulating in lung tissue and driving pathology via the aryl hydrocarbon receptor (AHR). This study evaluates the cell-specific contributions of kyn-mediated AHR signalin...

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Literature Corpus work: 49985528-e6cf-5aed-a105-474d4c1d781f
DOI: 10.64898/2026.07.21.738475

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