Acetoacetate Ameliorates Skin Fibrosis by Modulating TGF-β1/Smad2/3 Signaling Pathway

Abstract excerpt

<title>Abstract</title> <p>Skin fibrosis is a progressive pathologic outcome of prolonged healing of cutaneous wound which has been well accepted as a metabolic disease in recent study. However, the impact of ketone body metabolism on the development of cutaneous fibrosis remains largely unknown. Here, we found that ketone body metabolism was impaired in both human scars and bleomycin induced skin fibrogenesis of...

Topics

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• Acne and Rosacea Treatments and Effects
• Aldose Reductase and Taurine
• Dermatologic Treatments and Research
• Diabetic Foot Ulcer Assessment and Management
• Mesenchymal stem cell research
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Prenatal Substance Exposure Effects
• Wound Healing and Treatments

Identifiers and source

Literature Corpus work

3f273d12-43ec-5ee1-a388-c9ac25504584

DOI

10.21203/rs.3.rs-5282248/v1