Article

Dietary tryptophan mitigates lung ischemia-reperfusion injury via microbiota-derived indole-3-propionate and aryl hydrocarbon receptor signaling

2026-04-06

Abstract excerpt

<h4>Background</h4> Lung ischemia–reperfusion (IR) injury drives early morbidity after lung transplantation and cardiothoracic surgery, yet targeted preventive therapies are lacking. The gut–lung axis and microbiota-derived tryptophan metabolites, including indole-3-propionate (IPA), may regulate pulmonary immunity and inflammation. We investigated whether a tryptophan-rich (Trp-Rich) diet attenuates sterile lung...

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Literature Corpus work: b68736bd-f1df-5aec-9cef-03130d2d2d6f
DOI: 10.64898/2026.04.02.714281

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