Article

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

2024-10-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Exposure to repetitive head impacts (RHI) is associated with increased risk for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, and other neuropathological changes. Biological drivers of RHI-related neurodegeneration are not well understood. We interrogated the plasma proteome in aging adults with prior RHI compared to healthy controls (CTL) and indivi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42f3699c-5adf-53b3-be46-1088e6b797a9
DOI: 10.1101/2024.10.01.616097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathyDOI 10.1101/2024.10.01.616097Read

A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy.Semantic proximity Read

Inflammation and neuronal gene expression changes differ in early vs late chronic traumatic encephalopathy brainSemantic proximity Read

Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathySemantic proximity Read

Proteomic Analysis of Human Chronic Traumatic Encephalopathy Brain Implicates Proteasome and Ribosome Dysfunction in Disease ProgressionSemantic proximity Read

Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brainSemantic proximity Read

Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brainSemantic proximity Read

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral SclerosisSemantic proximity Read

Trajectories of blood-based protein biomarkers in chronic traumatic brain injurySemantic proximity Read

Carbonyl stress primes the metastable aging brain for Alzheimer’s diseaseSemantic proximity Read

Cellular Aging Signatures in the Plasma Proteome Record Human Health and DiseaseSemantic proximity Read

Protein Predictors of Worsening Cerebral Edema in Traumatic Brain Injury in Critically Ill PatientsSemantic proximity Read

Brain-wide alterations revealed by spatial transcriptomic and proteomic analyses in COVID-19 infectionSemantic proximity Read