Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target

11 Aug 2022

Abstract excerpt

BACKGROUND: The etiology of mild traumatic brain injury (mTBI) remains elusive due to the tissue and cellular heterogeneity of the affected brain regions that underlie cognitive impairments and subsequent neurological disorders. This complexity is further exacerbated by disrupted circuits within and between cell populations across brain regions and the periphery, which occur at different timescales and in spatial...

Source

Identifiers

PMID: 35951114
DOI: 10.1007/s00018-022-04495-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic targetPMID 35951114Read ↗

Systems spatiotemporal dynamics of traumatic brain injury at single cell resolution reveals humanin as a therapeutic targetSemantic proximity Read ↗

Thyroid hormone T4 mitigates traumatic brain injury in mice by dynamically remodeling cell type specific genes, pathways, and networks in hippocampus and frontal cortexSemantic proximity Read ↗

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal CortexSemantic proximity Read ↗

Single-Cell Profiling Resolved Transcriptional Alterations and Lineage Dynamics of Subventricular Zone after Mild Traumatic Brain InjurySemantic proximity Read ↗

Injury-induced CTE-like pathology emerges in a human multicellular <i>in vitro</i> brain model and reveals mitochondrial and neurovascular regulationSemantic proximity Read ↗

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain InjurySemantic proximity Read ↗

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortexSemantic proximity Read ↗

Single‐cell RNA ‐sequencing analysis reveals enhanced non‐canonical neurotrophic factor signaling in the subacute phase of traumatic brain injurySemantic proximity Read ↗

Transcriptional Pathology Evolves over Time in Rat Hippocampus after Lateral Fluid Percussion Traumatic Brain InjurySemantic proximity Read ↗

Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathySemantic proximity Read ↗

Integration of single-cell and bulk RNA sequencing data reveals key cell types and regulators in traumatic brain injurySemantic proximity Read ↗

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.