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Article

Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding

11 Apr 2017

Abstract excerpt

Genetic and phenotypic heterogeneity of human leukemia is thought to drive leukemia progression through a Darwinian process of selection and evolution of increasingly malignant clones. However, the lack of markers that uniquely identify individual leukemia clones precludes high-resolution tracing of their clonal dynamics. Here, we use cellular barcoding to analyze the clonal behavior of patient-derived...

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PMID: 28396495
DOI: 10.1182/blood-2016-12-758250

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