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Targeting Mitochondrial Calcium Homeostasis via novel S100A9 Inhibitor B2 as a Promising Agent Against AML

2025-10-05

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) remains difficult to treat in the relapsed or refractory (R/R) setting due to limited therapeutic targets and the emergence of drug resistance. Through integrative analysis of BeatAML, TCGA, and GEO datasets, we identified S100A9 as a gene highly associated with disease progression and poor treatment response in R/R AML. Functional assays demonstrated that m...

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Literature Corpus work: 2d247ee9-34ca-5e60-9334-11963602160a
DOI: 10.21203/rs.3.rs-7531512/v1

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