Article

Cheminformatic identification of small molecules targeting acute myeloid leukemia

2025-05-24

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis and high relapse rates when treated with cytotoxic chemotherapeutics. Previously, we identified a family of small molecules that modulate mitochondrial function, referred to as PS127-family compounds. These drugs were selectively toxic to AML and were characterized by two predicted functions: apoptotic agonism and thioredoxi...

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Literature Corpus work: 408741e5-5062-5cf9-90d6-bd32736ed3f2
DOI: 10.1101/2025.05.20.655224

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