Article

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

2023-10-03

Abstract excerpt

We previously reported that acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL2, creating a therapeutic opportunity to target LSCs using the BCL2 inhibitor drug venetoclax. While venetoclax-based regimens have indeed shown promising clinical activity, the emergence of drug resistance is prevalent. Thu...

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Literature Corpus work: 93dca456-e9e5-55b0-aacd-cb3602ce83dc
DOI: 10.1101/2023.10.02.560330

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