Article
The interaction between NPMc+ and Orai1 induces abnormal calcium influx to facilitate leukemogenesis.
The FEBS journal - 1 Sept 2026
Zhang Wenhao, Liang Chuangxuan, Zhang Lulu, Liu Xinglin, Zhang Zhenyu, Guo Huarong, Jia Jie, Chen Xin, Shang Hongxin, Zheng Xuena, Qin Jun, Li Shan, Liu Danwen, Wu Fuyun
Abstract excerpt
Nucleophosmin 1 (NPM1) is a ubiquitously expressed phosphoprotein, mainly located in the nucleolus. It is overexpressed in solid tumors and considered a key target in cancer therapy. NPM1 mutations are the most common genetic abnormalities in acute myeloid leukemia (AML), where they are found in about 30% of patients. In AML, NPM1 mutations result in the cytoplasmic localization of the mutant protein NPMc+....
Read the complete abstract on PubMedTopics
- Nucleophosmin
- Humans
- ORAI1 Protein
- Calcium
- Nuclear Proteins
- Leukemia, Myeloid, Acute