Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting S100A9 protein affects mTOR-ER stress signaling and increases venetoclax sensitivity in Acute Myeloid Leukemia

18 Dec 2023

Abstract excerpt

Acute Myeloid Leukemia (AML) is a heterogeneous disease with limited treatment options and a high demand for novel targeted therapies. Since myeloid-related protein S100A9 is abundantly expressed in AML, we aimed to unravel the therapeutic impact and underlying mechanisms of targeting both intracellular and extracellular S100A9 protein in AML cell lines and primary patient samples. S100A9 silencing in AML cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Clusterin in disease pathology
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38110349
DOI: 10.1038/s41408-023-00962-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting S100A9 protein affects mTOR-ER stress signaling and increases venetoclax sensitivity in Acute Myeloid LeukemiaPMID 38110349Read ↗

Targeting Mitochondrial Calcium Homeostasis via novel S100A9 Inhibitor B2 as a Promising Agent Against AMLSemantic proximity Read ↗

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AMLSemantic proximity Read ↗

Roles of S100 family members in drug resistance in tumors: Status and prospectsSemantic proximity Read ↗

Cheminformatic identification of small molecules targeting acute myeloid leukemiaSemantic proximity Read ↗

Preclinical Efficacy of Tasquinimod in Myelodysplastic Neoplasms: Restoring Erythropoiesis and Mitigating Bone LossSemantic proximity Read ↗

Mitochondrial abnormalities as a target of intervention in acute myeloid leukemiaSemantic proximity Read ↗

HDAC3-YY1-RAB5A axis remodels AML-supportive niche by modulating mitochondrial homeostasis in bone marrow stromal cellsSemantic proximity Read ↗

Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress responseSemantic proximity Read ↗

Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathwaySemantic proximity Read ↗

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axisSemantic proximity Read ↗

ASAH1-mediated sphingolipid metabolic reprogramming in venetoclax resistance of AML: beyond the monocytic phenotypes.Semantic proximity Read ↗

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial CalciumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.