Article

Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia

2019-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that the ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine (AraC)-resistant leukemic cells from both AML cell lines and patient samples in vivo and in vitro . CD39 cell surface expression and activity is increased in AML patients up...

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Literature Corpus work: d1b5ced1-9f4c-5bf3-ba01-ce625a7f1ac6
DOI: 10.1101/806992

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