Article
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science (New York, N.Y.) - 17 Jan 1992
de Vos A M, Ultsch M, Kossiakoff A A
Abstract excerpt
Binding of human growth hormone (hGH) to its receptor is required for regulation of normal human growth and development. Examination of the 2.8 angstrom crystal structure of the complex between the hormone and the extracellular domain of its receptor (hGHbp) showed that the complex consists of on...
Topics
- Binding Sites
- Crystallography
- Growth Hormone
- Humans
- Hydrogen Bonding
- Models, Molecular
- Molecular Structure
- Mutation
- Receptors, Somatotropin
- Signal Transduction