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Article

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.

Science (New York, N.Y.) - 17 Jan 1992

de Vos A M, Ultsch M, Kossiakoff A A

Abstract excerpt

Binding of human growth hormone (hGH) to its receptor is required for regulation of normal human growth and development. Examination of the 2.8 angstrom crystal structure of the complex between the hormone and the extracellular domain of its receptor (hGHbp) showed that the complex consists of one molecule of growth hormone per two molecules of receptor. The hormone is a four-helix bundle with an unusual...

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Identifiers

PMID: 1549776
DOI: 10.1126/science.1549776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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