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In Silico Insights Into Growth Hormone Variants: Structural and Functional Implications of Breed-Specific SNPs in Sheep.

Chemistry & biodiversity - 1 Feb 2026

Mahdi Manar Hussam, Aljubouri Thamer R S, Al-Shuhaib Mohammed Baqur S

Abstract excerpt

Growth hormone (GH) is a key determinant of various productive traits in sheep; however, the genetic diversity of GH across breeds and the structural and functional consequences of breed-specific SNPs remain largely unexplored. Based on multiple sequence alignments of the GH sequences, 14 models were suggested, and 11 of them were validated using phylogenetic analysis. Most of the SNPs exhibited various...

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PMID: 41698011
DOI: 10.1002/cbdv.202503118

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GHR

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