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Article

Spine pruning in 5xFAD mice starts on basal dendrites of layer 5 pyramidal neurons.

Brain structure & function - 1 Mar 2014

Crowe Sarah E, Ellis-Davies Graham C R

Abstract excerpt

Transgenic mice with Alzheimer's disease (AD) mutations have been widely used to model changes in neuronal structure and function. While there are clear gross structural changes in post-mortem brains of AD patients, most mouse models of AD do not recapitulate the considerable loss of neurons. Furthermore, possible connections between early subtle structural changes and the loss of neurons are difficult to study....

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Identifiers

PMID: 23417057
DOI: 10.1007/s00429-013-0518-6
PMCID: PMC4157364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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