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Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA.

Nucleic acids research - 2 Dec 2021

Shi Honglue, Kimsey Isaac J, Gu Stephanie, Liu Hsuan-Fu, Pham Uyen, Schumacher Maria A, Al-Hashimi Hashim M

Abstract excerpt

Watson-Crick base pairs (bps) are the fundamental unit of genetic information and the building blocks of the DNA double helix. However, A-T and G-C can also form alternative 'Hoogsteen' bps, expanding the functional complexity of DNA. We developed 'Hoog-finder', which uses structural fingerprints to rapidly screen Hoogsteen bps, which may have been mismodeled as Watson-Crick in crystal structures of protein-DNA...

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Identifiers

PMID: 34792150
DOI: 10.1093/nar/gkab936
PMCID: PMC8643651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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