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Both isoforms of ketohexokinase are dispensable for normal growth and development

15 Sept 2010

Abstract excerpt

Dietary fructose intake has dramatically increased over recent decades and is implicated in the high rates of obesity, hypertension, and type 2 diabetes (metabolic syndrome) in Western societies. The molecular determinants of this epidemiologic correlation are incompletely defined, but high-flux fructose catabolism initiated by ketohexokinase (Khk, fructokinase) is believed to be important. The Khk gene encodes...

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PMID: 20841500
DOI: 10.1152/physiolgenomics.00128.2010

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