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Aiding Cancer’s “Sweet Tooth”: Role of Hexokinases in Metabolic Reprogramming

4 Apr 2023

Abstract excerpt

Hexokinases (HKs) convert hexose sugars to hexose-6-phosphate, thus trapping them inside cells to meet the synthetic and energetic demands. HKs participate in various standard and altered physiological processes, including cancer, primarily through the reprogramming of cellular metabolism. Four canonical HKs have been identified with different expression patterns across tissues. HKs 1-3 play a role in glucose...

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PMID: 37109475
DOI: 10.3390/life13040946

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