Article

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD

2023-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome, and is estimated to affect one billion individuals worldwide. An increased intake of a high-fat diet (HFD) and sugar-sweetened beverages are risk-factors for NAFLD development, but how their combined intake promotes progression to a more severe form of liver injury is unknown. Here we show that fructose met...

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Literature Corpus work: ba9eeb8f-e4cb-507d-9d54-5a85a9cbcc0b
DOI: 10.1101/2023.01.27.525605

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