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Article

Allosteric Inhibition of the Epidermal Growth Factor Receptor.

Biochemistry - 23 Feb 2021

Sinclair Julie K L, Robertson Wesley E, Mozumdar Deepto, Quach Kim, Schepartz Alanna

Abstract excerpt

We previously reported a family of hydrocarbon-stapled peptides designed to interact with the epidermal growth factor receptor (EGFR) juxtamembrane (JM) segment, blocking its ability to form a coiled coil dimer that is essential for receptor activation. These hydrocarbon-stapled peptides, most notably E1S, decreased the proliferation of cell lines that express wild-type EGFR (H2030 and A431) as well as those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33557518
DOI: 10.1021/acs.biochem.0c00978
PMCID: PMC8815332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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