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Analysis of EGFR binding hotspots for design of new EGFR inhibitory biologics

14 Sept 2024

Abstract excerpt

The epidermal growth factor (EGF) receptor (EGFR) is activated by the binding of one of seven EGF-like ligands to its ectodomain. Ligand binding results in EGFR dimerization and stabilization of the active receptor conformation subsequently leading to activation of downstream signaling. Aberrant activation of EGFR contributes to cancer progression through EGFR overexpression/amplification, modulation of its...

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PMID: 39275996
DOI: 10.1002/pro.5141

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