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Article

Inhibiting epidermal growth factor receptor at a distance.

Journal of the American Chemical Society - 13 Aug 2014

Sinclair Julie K-L, Denton Elizabeth V, Schepartz Alanna

Abstract excerpt

The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molecules that inhibit the kinase activity of EGFR in a new way, by competing with formation of an essential intradimer coiled coil containing the juxtamembrane segment...

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Identifiers

PMID: 25075632
DOI: 10.1021/ja504076t
PMCID: PMC4140499

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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