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Article

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.

Molecular cell - 5 May 2016

Runkle Kristin B, Kharbanda Akriti, Stypulkowski Ewa, Cao Xing-Jun, Wang Wei, Garcia Benjamin A, Witze Eric S

Abstract excerpt

Inappropriate activation of the receptor tyrosine kinase EGFR contributes to a variety of human malignancies. Here we show a mechanism to induce vulnerability to an existing first line treatment for EGFR-driven cancers. We find that inhibiting the palmitoyltransferase DHHC20 creates a dependence on EGFR signaling for cancer cell survival. The loss of palmitoylation increases sustained EGFR signal activation and...

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Identifiers

PMID: 27153536
DOI: 10.1016/j.molcel.2016.04.003
PMCID: PMC4860254

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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