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Article

Discrete Coiled Coil Rotamers Form within the EGFRvIII Juxtamembrane Domain.

Biochemistry - 20 Oct 2020

Mozumdar Deepto, Doerner Amy, Zhang Justin Y, Rafizadeh Diane N, Schepartz Alanna

Abstract excerpt

Mutations in the epidermal growth factor receptor (EGFR) extracellular domain (ECD) are implicated in the development of glioblastoma multiforme (GBM), which is a highly aggressive form of brain cancer. Of particular interest to GBM is the EGFR variant known as EGFRvIII, which is distinguished by an in-frame deletion of exons 2-7, which encode ECD residues 6-273. Included within the deleted region is an...

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PMID: 32941004
DOI: 10.1021/acs.biochem.0c00641
PMCID: PMC7906117

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