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The MET Oncogene Network of Interacting Cell Surface Proteins

21 Dec 2024

Abstract excerpt

The MET oncogene, encoding the hepatocyte growth factor (HGF) receptor, plays a key role in tumorigenesis, invasion, and resistance to therapy, yet its full biological functions and activation mechanisms remain incompletely understood. A feature of MET is its extensive interaction network, encompassing the following: (i) receptor tyrosine kinases (RTKs); (ii) co-receptors (e.g., CDCP1, Neuropilin1); (iii)...

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PMID: 39769452
DOI: 10.3390/ijms252413692

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