Article

Estimating the proportion of disease heritability mediated by gene expression levels

2017-03-18

Abstract excerpt

Disease risk variants identified by GWAS are predominantly noncoding, suggesting that gene regulation plays an important role. eQTL studies in unaffected individuals are often used to link disease-associated variants with the genes they regulate, relying on the hypothesis that noncoding regulatory effects are mediated by steady-state expression levels. To test this hypothesis, we developed a method to estimate the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a17e6293-7b77-53ce-a969-610feb0c9668
DOI: 10.1101/118018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Estimating the proportion of disease heritability mediated by gene expression levelsDOI 10.1101/118018Read

Quantifying genetic effects on disease mediated by assayed gene expression levelsSemantic proximity Read

Quantifying genetic effects on disease mediated by assayed gene expression levels.Semantic proximity Read

Leveraging gene co-regulation to identify gene sets enriched for disease heritability.Semantic proximity Read

Leveraging gene co-regulation to identify gene sets enriched for disease heritabilitySemantic proximity Read

Modeling tissue co-regulation to estimate tissue-specific contributions to diseaseSemantic proximity Read

Leveraging genome-wide effects on gene expression to identify disease-critical genes with <i>trans</i> -genetic componentsSemantic proximity Read

Partitioning gene-based variance of complex traits by gene score regressionSemantic proximity Read

Partitioning gene-based variance of complex traits by gene score regression.Semantic proximity Read

Estimating the causal tissues for complex traits and diseases.Semantic proximity Read

Local genetic effects on gene expression across 44 human tissuesSemantic proximity Read

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read

Modeling tissue co-regulation estimates tissue-specific contributions to disease.Semantic proximity Read