Article

Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer

2026-02-05

Abstract excerpt

<title>Abstract</title> <p>Liquid biopsies can detect actionable mutations and infer broad tumor states from genome-wide cfDNA measurements, but quantitative transcriptome-like phenotyping at single gene resolution still largely requires tissue. Here, we asked whether 6-base whole-genome sequencing that jointly quantifies 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) could infer gene expression direct...

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Literature Corpus work: 2cc9f04d-7e46-5d8e-83d9-f0b79cb45911
DOI: 10.21203/rs.3.rs-8778762/v1

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