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Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer

1 Mar 2023

Abstract excerpt

Liquid biopsy has proven valuable in identifying individual genetic alterations; however, the ability of plasma ctDNA to capture complex tumor phenotypes with clinical value is unknown. To address this question, we have performed 0.5X shallow whole-genome sequencing in plasma from 459 patients with metastatic breast cancer, including 245 patients treated with endocrine therapy and a CDK4/6 inhibitor (ET +...

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PMID: 36859416
DOI: 10.1038/s41467-023-36801-9

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