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5-hydroxymethylcytosine sequencing in plasma cell-free DNA identifies unique epigenomic features in prostate cancer patients resistant to androgen deprivation therapies

2023-10-16

Abstract excerpt

<h4>Background</h4> Currently, no biomarkers are available to identify resistance to androgen-deprivation therapies (ADT) in men with hormone-naive prostate cancer. Since 5-hydroxymethylcytosines (5hmC) in gene body are associated with gene activation, in this study, we evaluated whether 5hmC signatures in cell-free DNA (cfDNA) predicts early resistance to ADT. <h4>Results</h4> We collected a total of 139 serial p...

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Literature Corpus work: 5c4ff115-2bee-54d2-b69f-bf7ec83b1a30
DOI: 10.1101/2023.10.13.23296758

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