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Article

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer.

Journal of the National Cancer Institute - 1 Dec 2017

Wyatt Alexander W, Annala Matti, Aggarwal Rahul, Beja Kevin, Feng Felix, Youngren Jack, Foye Adam, Lloyd Paul, Nykter Matti, Beer Tomasz M, Alumkal Joshi J, Thomas George V, Reiter Robert E, Rettig Matthew B, Evans Christopher P, Gao Allen C, Chi Kim N, Small Eric J, Gleave Martin E

Abstract excerpt

BACKGROUND: Real-time knowledge of the somatic genome can influence management of patients with metastatic castration-resistant prostate cancer (mCRPC). While routine metastatic tissue biopsy is challenging in mCRPC, plasma circulating tumor DNA (ctDNA) has emerged as a minimally invasive tool to sample the tumor genome. However, no systematic comparisons of matched "liquid" and "solid" biopsies have been...

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Adenomatous Polyposis Coli Protein
Circulating Tumor DNA
Class Ia Phosphatidylinositol 3-Kinase
Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms, Castration-Resistant

Retinoblastoma Binding Proteins

Wnt Signaling Pathway

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Open in PubMed Open full text

Identifiers

PMID: 29206995
DOI: 10.1093/jnci/djx118
PMCID: PMC6440274

Genes

APC
BRCA2
PTEN
SPOP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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