Article

Genomic alterations in the YAP/TAZ pathway are associated with stem cell-like castration-resistant prostate cancer

2025-07-02

Abstract excerpt

Castration-resistant prostate cancer (CRPC) is an aggressive disease exhibiting multiple epigenomic subtypes: androgen receptor-dependent CRPC-AR, and lineage plastic subtypes CRPC-SCL (stem cell-like), CRPC-WNT (Wnt-dependent), and CRPC-NE (neuroendocrine). By transcriptomic profiling of tissue, and whole-genome sequencing (WGS) of tissue and cell-free DNA (cfDNA) from 500 samples, we relate genomic variants with...

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Literature Corpus work: 0e0e121b-3628-52d0-a9e9-7b6e6d354f01
DOI: 10.1101/2025.07.01.25330467

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