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The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors

29 Oct 2022

Abstract excerpt

Metastatic prostate cancer remains a major clinical challenge and metastatic lesions are highly heterogeneous and difficult to biopsy. Liquid biopsy provides opportunities to gain insights into the underlying biology. Here, using the highly sensitive enrichment-based sequencing technology, we provide analysis of 60 and 175 plasma DNA methylomes from patients with localized and metastatic prostate cancer,...

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PMID: 36309516
DOI: 10.1038/s41467-022-34012-2

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