Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.

Nature - 1 Aug 2022

Herberts Cameron, Annala Matti, Sipola Joonatan, Ng Sarah W S, Chen Xinyi E, Nurminen Anssi, Korhonen Olga V, Munzur Aslı D, Beja Kevin, Schönlau Elena, Bernales Cecily Q, Ritch Elie, Bacon Jack V W, Lack Nathan A, Nykter Matti, Aggarwal Rahul, Small Eric J, Gleave Martin E, Quigley David A, Feng Felix Y, Chi Kim N, Wyatt Alexander W

Abstract excerpt

Circulating tumour DNA (ctDNA) in blood plasma is an emerging tool for clinical cancer genotyping and longitudinal disease monitoring1. However, owing to past emphasis on targeted and low-resolution profiling approaches, our understanding of the distinct populations that comprise bulk ctDNA is incomplete2-12. Here we perform deep whole-genome sequencing of serial plasma and synchronous metastases in patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgen Receptor Antagonists
Share to Circulating Tumor DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Liquid Biopsy

Share to Neoplasm Metastasis

Share to Nucleosomes

Share to Receptors, Androgen

Share to RNA, Neoplasm

Source

Identifiers

PMID: 35859180
DOI: 10.1038/s41586-022-04975-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.PMID 35859180Read ↗

Longitudinal Profiling of Circulating Tumor DNA Reveals the Evolutionary Dynamics of Metastatic Prostate Cancer during Serial TherapySemantic proximity Read ↗

Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis.Semantic proximity Read ↗

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesisSemantic proximity Read ↗

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesisSemantic proximity Read ↗

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells.Semantic proximity Read ↗

Circulating tumor cells capture disease evolution in advanced prostate cancer.Semantic proximity Read ↗

Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms.Semantic proximity Read ↗

Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway InhibitionSemantic proximity Read ↗

Single-cell genomic analysis of cancer cells from one treatment-naïve patient with metastatic prostate cancer.Semantic proximity Read ↗

Circulating tumor DNA and tissue complementarily detect genomic alterations in metastatic hormone-sensitive prostate cancerSemantic proximity Read ↗

Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancerSemantic proximity Read ↗

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.