Article

Allele-specific chromatin modifications of HPV-associated extrachromosomal DNAs in cervical cancer

2026-07-20

Abstract excerpt

Cervical cancer, a human papillomavirus (HPV) driven malignancy, is the fourth deadliest cancer in females. Approximately 25% of primary cervical cancers contain circular structures called extrachromosomal DNAs (ecDNAs), which can be entirely composed of human DNA (human-only ecDNAs) or a combination of HPV and human DNA sequences (HPV-human hybrid ecDNAs). Human-only ecDNAs harbour cancer-driving oncogenes, but e...

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Literature Corpus work: 4a0ac994-5c94-5335-830b-ef44225a6983
DOI: 10.64898/2026.07.15.733834

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