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The human knockout phenotype of <i><scp>PADI6</scp></i> is female sterility caused by cleavage failure of their fertilized eggs

12 Oct 2016

Abstract excerpt

Naturally occurring human knockouts have greatly expanded our understanding of the medical relevance of genes, or lack thereof 1. Indeed, while biallelic inactivation of genes can result in severe Mendelian disorders, other genes seem to be tolerated when knocked out 2. We have been studying embryonic lethality as an extreme Mendelian phenotypic consequence of human knockout events by taking advantage of the...

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PMID: 27730629
DOI: 10.1111/cge.12866

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The human knockout phenotype of <i><scp>PADI6</scp></i> is female sterility caused by cleavage failure of their fertilized eggsPMID 27730629Read ↗

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