Article

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

2022-07-30

Abstract excerpt

Assembly of ribosomal subunits into active ribosomal complexes is integral to protein synthesis. Release of eIF6 from the 60S ribosomal subunit primes 60S to associate with the 40S subunit and engage in translation. The dynamics of eIF6 interaction with the uL14 (RPL23) interface of 60S and its regulation by somatic mutations acquired in Shwachman-Diamond Syndrome (SDS) is yet to be clearly understood. Here, by us...

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Literature Corpus work: 2eadfbfe-2391-5dea-b684-74299a1658d4
DOI: 10.1101/2022.07.29.502049

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