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Article

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

Journal of molecular biology - 7 Nov 2008

Tsai Chung-Jung, Sauna Zuben E, Kimchi-Sarfaty Chava, Ambudkar Suresh V, Gottesman Michael M, Nussinov Ruth

Abstract excerpt

How can we understand a case in which a given amino acid sequence folds into structurally and functionally distinct molecules? Synonymous single-nucleotide polymorphisms in the MDR1 (multidrug resistance 1 or ABCB1) gene involving frequent-to-rare codon substitutions lead to identical protein sequences. Remarkably, these alternative sequences give a protein product with similar but different structures and...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18722384
DOI: 10.1016/j.jmb.2008.08.012
PMCID: PMC2628389

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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