Article
The ribosome lowers the entropic penalty of protein folding.
Nature - 1 Sept 2024
Streit Julian O, Bukvin Ivana V, Chan Sammy H S, Bashir Shahzad, Woodburn Lauren F, Włodarski Tomasz, Figueiredo Angelo Miguel, Jurkeviciute Gabija, Sidhu Haneesh K, Hornby Charity R, Waudby Christopher A, Cabrita Lisa D, Cassaignau Anaïs M E, Christodoulou John
Abstract excerpt
Most proteins fold during biosynthesis on the ribosome1, and co-translational folding energetics, pathways and outcomes of many proteins have been found to differ considerably from those in refolding studies2-10. The origin of this folding modulation by the ribosome has remained unknown. Here we have determined atomistic structures of the unfolded state of a model protein on and off the ribosome, which reveal...
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