Article

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

2017-04-24

Abstract excerpt

Human mtDNA contains three promoters, suggesting a need for differential expression of the mitochondrial genome. Studies of mitochondrial transcription have used a reductionist approach, perhaps masking differential regulation. Here we evaluate transcription from light-strand (LSP) and heavy-strand (HSP1) promoters using templates that mimic their natural context. These studies reveal sequences upstream, hypervari...

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Literature Corpus work: 2c75db0c-263a-55e4-b091-d33e3941b5ee
DOI: 10.1101/129908

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