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Article

Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.

Molecular and cellular biology - 1 Mar 1991

Moraes C T, Andreetta F, Bonilla E, Shanske S, DiMauro S, Schon E A

Abstract excerpt

We identified two patients with progressive external ophthalmoplegia, a mitochondrial disease, who harbored a population of partially deleted mitochondrial DNA (mtDNA) with unusual properties. These molecules were deleted from mtDNA positions 548 to 4,442 and encompassed not only rRNA sequences but the heavy-strand promoter region as well. A 13-bp direct repeat was found flanking the breakpoint precisely, with...

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Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

Share to Repetitive Sequences, Nucleic Acid

Source

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Identifiers

PMID: 1996112
DOI: 10.1128/mcb.11.3.1631-1637.1991
PMCID: PMC369459

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Source receipt: pubmed, retrieved 7 Sept 2026.

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