Article

Deep learning molecular interaction motifs from Receptor structure alone

2025-01-15

Abstract excerpt

Interactions of proteins with other molecules are often mediated by a set of critical binding motifs on their surfaces. The majority of traditional binder design relied on motifs borrowed from known binder molecules, which highly restricted its applicability to novel targets or to new binding sites. In this work, we present a deep learning network MotifGen that predicts potential binder motifs directly from recept...

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Identifiers and source

Literature Corpus work: db151205-cc06-5803-b41c-e1e1b493ed74
DOI: 10.1101/2025.01.13.632880

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