Article

Adapting protein language models for structure-conditioned design

2024-08-03

Abstract excerpt

Generative models for protein design trained on experimentally determined structures have proven useful for a variety of design tasks. However, such methods are limited by the quantity and diversity of structures used for training, which represent a small, biased fraction of protein space. Here, we describe proseLM, a method for protein sequence design based on adaptation of protein language models to incorporate...

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Literature Corpus work: 5a9eb818-ca22-5894-b5be-6993430ba691
DOI: 10.1101/2024.08.03.606485

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