Article

BC-Design: A Biochemistry-Aware Framework for Inverse Protein Design

2024-11-03

Abstract excerpt

Inverse protein design (IPD) extends the classical problem of inverse protein folding (IPF) by not only recovering a sequence compatible with a given backbone geometry but also generating a range of new sequences that satisfy the physicochemical constraints required for a stable fold with a specified (often designed) function. Recent progress has incorporated biochemical properties as discrete per-residue features...

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Literature Corpus work: 5af80b37-1ded-51bc-a54d-067fe8eed6d1
DOI: 10.1101/2024.10.28.620755

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